Senior Research Investigator in Medicinal chemistry
Submitted by admin on Tue, 03/15/2011 - 16:06
BeiGene Bio, a fully integrated biotech company focused on anti-cancerous drugs research and development, is currently looking for enthusiastic PhD level of Senior Research Investigators in medicinal chemistry who will design synthetic routes and synthesize compounds. This individual will also be a leader in a drug discovery program. As a member of the drug discovery team you will impact the discovery and development of agents to treat various cancers.
Responsibilities
- Design and execution of multi-step syntheses of new compounds and analogues of existing lead molecules for biological evaluation on milligram to gram scale.
- Conduct appropriate synthetic follow-up studies to optimize bioactivity obtained in support of internal and collaborative programs.
- Optimization of synthetic routes for specific new product candidates.
- Design and construction of focused and targeted chemical libraries for screening in selected biological target systems utilizing parallel synthesis techniques.
- Development and synthesis of novel fragments for incorporation into target molecules.
- Maintain up-to-date records for all work performed and ensure a safe workplace.
- Mentor and supervise associate scientists and serve as a source of synthetic chemistry expertise.
- Manage external chemists and collaborations resulting in the delivery of drug candidates on aggressive time lines.
- Actively follow scientific advancements and literature within the area of research interest.
Qualifications
- Ph.D. in Organic or Medicinal Chemistry with 0-3 years industrial experience
- Demonstrated proficiency and expertise in multi-step synthesis with a thorough knowledge of modern organic chemistry, purification methods and analytical techniques
- Ability to solve challenging chemistry hurdles effectively
- Ability to meet challenging timelines and flexibility to adapt to changing project requirements
- Ability to solve medicinal chemistry problems via effective structure-activity relationship (SAR)
- Ability to lead a medicinal chemistry project team scientifically and organizationally.
- Proficiency with computers including standard office programs, use of chemical structure drawing programs, presentation preparation and database searching
- Good oral and written communication skills
Source::
Internet